the gag reel

I know memory isn't a passive record of events.  It's more like an ongoing re-construction. When this happens, I consistently get the order of things wrong.  I often confuse what happened one time for something that happened another time.  Last night I was watching a gag reel from season five of Parks and Recreation. In an early scene, Andy asks his young wife April if she's pregnant. April responds saying: "Nooo, we've talked about this ..and what do I always tell you? We're going to wait till we're 50 to have children ..!" In another scene, Andy and April are giving Ben advice for a successful marriage. Andy asks April what other tips they can give him (that she heard from a friend). April replies: "She said 'don't pull out till I scream'!" Now, at the end of the reel, what do I remember?  In the first scene where they talk about having children ..I remember April saying: "Nooo, we've talked about this ..and what do I always tell you? 'Don't pull out till I scream'!" I put the dialogue from the other scene  here. It wasn't until I replayed the gag reel that I realized my mistake. Although my recollection didn't follow the actual order of events ..it made sense and even retained some of it's humor.  Perhaps we remember semantic-relationships better than chronological order.

Pioneers of sight

 Watching a hawk circle the canyon overhead starts out as packets of light or ‘photons’ striking my retina. How these photons strike the retina and which pathways they activate in the brain tell me what I’m seeing. Photons landing in a specific orientation will travel pathways that construct its’ form (bird). When they hit adjacent areas in succession I’m informed of its’ motion and direction. And the length of time between hits tells me its’ speed. None of this was known before 1968 when David Hubel and Torten Wiesel first announced their research findings. And it wasn’t until 1981 that it was generally accepted and they earned the Nobel Prize in Neurophysiology and Medicine.

false memory

“Memory is not a passive record of things past. It's more like an ongoing construction-site, integrating and revising the past with events from the present and predictions about the future.”  [link]

How to plant a false memory by Dr. Susumu Tonegawa [link]: I’m skeptical. How is it possible to know what’s going on inside the head of a mouse ..let alone tell whether it’s true or not. I’m also intrigued. They say the fabric of memory is pliable and self-serving. It can be revised by the simple act of re-hashing things. Psychologist Elizabeth Loftus used to demonstrate this with eyewitness testimony. Neuroscientists have now replicated it with mice in a maze. Here’s how:

1. They narrow down a set of brain cells that get activated whenever a mouse enters a new location. Unfamiliar territory evokes a ‘neo-phobic’ response, which adds staying power to novel experience.
2. Then they create a new memory by stimulating the same set of cells and delivering an unpleasant jolt when the mouse enters a neutral part of the maze. The mouse ‘re-lives’ the experience of being in the location it explored before and couples it with the jolt. How do they know? The mouse avoids the location like never before.

They say memory serves as a road map to the future. However humans can play pretty loose with it .. reminiscing or ruminating about things ..which may make us more prone to revising the past. I don’t know if this has anything to do with it but I often recollect scenes from movies I enjoy. Lately I’ve been watching a lot of French films with the actress Audrey Tautou ..who I just adore. I also saw her in the movie ‘Da Vinci Code’ last night. This morning when Audrey Tautou popped into my head ..I mistook her for the character she plays in the movie. A character of potentially game-changing consequence to humanity. It felt eerie. It was just a flash but I’m wondering if this isn’t also some kind of false memory. Perhaps I’m overthinking it. I often blur the distinction between fantasy and reality. I know I confuse scenes from the movies with episodes from my past.

quantum tunnelling

In space, the powers of creation and destruction work differently. Matter forms ..dissolves ..then reappears in  a   s l o w e r   m a n n e r.  Matter that makes up you and me. On earth we’re refreshed at such high speeds ..particles disappear and reappear in essentially the same place ..making our position more or less predictable from one instant to the next. In space, however, it’s so cold that things take a little longer ..when measured in nano-seconds. So, instead of the high-speed collisions we see taking place here .. in space, particles are refreshed by means of quantum tunnelling  [link]. This means we could wink out of one place one moment and reappear in another place the next ..kind of like looking at someone through a strobe light. And not only that .. this kind of delay lowers the probability of particles sticking together ..meaning there’s a good chance that we could dissolve in the process.

Eight foot woman

brings down the recording industry. 

Brilliant use of the Internet to create a meaningful music exchange

cyber space

Looks like a pair of ski goggles with a cheap and easy interface ‘app’ to a video game console is all it takes to bring virtual reality into focus [link]. They’re called ‘Rift’ headsets and they perform close to high-end simulators used in flight training. They use motion-detectors developed for mobile computing and head-tracking sensors developed by psychophysicists. The result is faster response-time with minimal lens-distortion, which means you get a seamless look at the action in cyber space. They’re made by Oculus in Irvine and now come ready to use with the video game ‘Hawken’ (Meteor Entertainment).

PTS prevention study

What makes some people less susceptible to PTS ..? Nociceptin receptors in the amygdala. Nociceptin (NOP) is a compound found at the synapse that acts like an analgesic. Nociceptin receptors are part of the amygdala involved in conditioned fear. According to neuroscientist Raul Andero Gali, we can prevent PTSD-like symptoms from developing.

Animal model of PTS

Traumatic   ~>    Fear-Response   ~>   Extinction
   Event                 Conditioning              Training  

During extinction training, some animals unlearn fear response (freezing) more rapidly than others. Persistence of fear in absence of danger is a characteristic of PTS. So, what makes some animals less susceptible to PTS ..?

Study 1 – naturalistic observation

Study found that those who unlearn the fastest were those whose Nociceptin receptors were most active. Nociceptin is a natural occurring opiate in the brain that’s thought to dampen consolidation of fearful memories 

Study 2 – experimental method

Animals that received a drug during conditioning that activates Nociceptin receptors  quickly learned to stop fearing the tone during extinction training. NOP receptors may interfere with fear memory consolidation, with implications for prevention of PTSD after a traumatic event [link] [link].

Verbal fluency

The other day someone asked me what ‘verbal fluency’ meant. I wasn’t very convincing. So I did a little searching. Verbal fluency refers to the ability to quickly access your mental vocabulary.. selecting appropriate and discarding less appropriate words ..while speaking or writing. If you've ever struggled searching through synonyms in a thesaurus ..fell short of a witty comeback .. or failed to persuade someone of something you know well ..then you understand the importance of verbal fluency. Boosting or recovering a patients’ verbal fluency is one of the objectives of speech therapy. Verbal fluency eludes me a lot of the time. Oh well oh well..

Sexual development

“The onset of puberty is determined by a mix of genetic and environmental factors coming to bear on the hypothalamus of the brain.”  Margaret M McCarthy, Piece in the puzzle of puberty, Nature, February 2013.

Somatosensory awareness

Mindfulness starts with the body: Meditation has been practiced for over two millennia in Asian Buddhist traditions. It is said to involve the cultivation of experiential awareness of the present moment. This present-moment focus is thought to improve well-being by allowing individuals to become aware of sensations, emotions and thoughts that arise in the mind without judgment or reactivity. Over the last two decades, mindfulness-related treatments have become an increasingly common component of the healthcare system. A common set of mindfulness exercises have been shown to reduce distress in chronic pain and decrease risk of depression relapse. These practices require attending to breath and body sensations. Here, we offer a novel view. Somatic focus helps modulate 7–14 Hz alpha rhythms (brain waves) that play a key role in filtering inputs to primary sensory neocortex and organizing the flow of sensory information in the brain. In support of the framework, we describe our previous finding that meditation enhances attention in the primary somatosensory cortex. The framework allows us to make several predictions. In chronic pain, we predict somatic attention “de-biases” neuro activity, freeing up pain-focused resources. In depression relapse, we predict somatic attention competes with internally focused rumination, as internally focused cognitive processes (including working memory) rely on alpha filtering of sensory input. Somatic focus sensitizes practitioners to better detect and regulate when the mind wanders from its somatic focus. Enhanced regulation of somatic mind-wandering may be an important early stage of mindfulness training that leads to enhanced cognitive regulation and metacognition

From Frontiers in Neuroscience [ link ]

Buddhist parable

“I am going to give you big secret of the fountain of youth that will save you much money on cosmetics and plastic surgery: In stillness we do not age as quickly as those whose minds are constantly battling to hold their personalities together.”  ◊  Wing

Psychologists have reached the same conclusion. A large amount of mental activity is spent to making sure that what we say conforms to our personality. In a study titled Cognitive demand and self-presentation [link] they asked participants about a specific event. Participants often answered with an average case that best represented the image they were trying to maintain. That's a lot of work. Far easier to report an actual experience than compute an average.

Bilingual advantage

“If you walk into a room, where a million things can attract your attention, how does your mind pay attention to what you need to pay attention to without getting distracted?”  [link]

Speaking multiple languages may be an advantage in more ways than one: a new study suggests that bilinguals are speedier task-switchers than monolinguals [link]. Task-switching has real-world applications ..the ability to mentally “switch gears” and refocus on new goals.It is a valuable skill that has numerous practical uses. You use it to shift attention from the wheel to the road while driving, or to switch gears between offense and defense in a team sport. Bilingualism has already been associated with a number of cognitive advantages, and now a 2010 study from Language and Cognition has investigated how bilingualism might enhance crucial task-switching skills in young adults  This study contributes to a growing body of evidence suggesting that bilinguals enjoy enhanced executive control compared to monolinguals. Executive control refers to a combination of cognitive abilities—including task-switching—that help you make decisions, control impulses, and plan thoughtfully. It’s long been thought that constant management and monitoring of two languages improves executive control—a belief that this Carnegie Mellon study supports.

Navigating memory

“Here we propose that mechanisms of memory and planning have evolved from mechanisms of navigation in the physical world and hypothesize that the neuronal algorithms underlying navigation in mental space are fundamentally the same as those that underlie navigation in  physical space.”

From: Memory navigation and theta rhythm in the hippocampus [link]

György Buzsáki and Edvard I Moser

End of history illusion

“People regard the present as a watershed moment that will last the rest of their lives .. this ‘end of history illusion’ has consequences, leading people to overpay for future opportunities in light of their current preferences.” Daniel Gilbert 

This study examines the ‘end of history’ illusion [ link ]. A cognitive bias toward projecting present values and personal preferences into the future .. even when it’s clear that values and preferences change so dramatically. Guess that means I imagine myself willing to pay the same for concert tickets to see Lissie ten years from now .. even though I’m no longer that  interested in seeing someone like Sarah Bettens who was one of my favorites ten years ago.

Peer-mediated buzz

James Fowler, professor of psychology at UCSD, found that messages from our peers are more likely to initiate action than messages from a political committee [ link ]. Last year, Obama’s reelection committee learned the same thing [ link ]. They developed a system that leverages database technology and social-media to deliver their messages. In an instant, this system allows them to:

1. mobilize grassroots support for White House concerns 
2. provide White House support for local concerns

Apparently they took an extra step, conducted surveys ..and learned that nothing energizes participation better than ‘reciprocity’. Brilliant use of technology combined with Obama’s experience as a community organizer. Politically I’m independent and pretty damn naïve ..but I can see why this may give Republicans cause for alarm.

Puzzle Box

A fun way to learn to relax

Puzzlebox Orbit relies on EEG hardware from NeuroSky to capture brainwaves that signal attention and meditation. The more relaxed the player ..the higher and more controlled the helicopter goes [ link ].

Decision making

Decisions are mostly intuitive, logical explanations
catch-up milliseconds later ~ Robert Sapolsky [ link ]

Eyewitness testimony

Since 1975, Elizabeth Loftus has conducted research into the integrity of human memory. Her studies show that memory is not a video recording of things past. It’s suggestible and subject to laws of perception ..especially when we rely on it for eyewitness testimony [ link ].  Courtroom proceedings  back her claims. Convictions have been overturned due to faulty eyewitness testimony. Crimes are generally chaotic and the experience .. traumatic. In addition, the process of identifying suspects from a lineup or photo spread can be biased. The state of Oregon is the first to establish standards, based on these findings, to determine what qualifies as admissible evidence from eyewitness testimony [ link ]. For one, the eyewitness needs to be in a position to objectively observe the perpetrator during the commission of a crime ..not wounded or staring down the barrel of a gun. Two, lineups need to be conducted by someone who doesn’t know the identity of the suspect. And three, photos need to be presented sequentially, one at a time, the way we ordinarily run into people on the street ..not all at once.

GABA

GABA is the chief inhibitory neurotransmitter of the central nervous system. It is responsible for lowering excessive activity in the brain. Sedatives and tranquilizers act by enhancing the effects of GABA. When the potency of GABA is elevated for reasons unknown ..it results in a condition called hypersomnia or around-the-clock sleep, which can be very disruptive. It renders people unable to work or maintain relationships. Dr. David Rye found that a drug called flumazenil counteracts both tranquilizers and GABA in patients suffering hypersomnia. Furthermore it targets only people with high sensitivity to GABA while leaving people with normal GABA response alone ..meaning it gets closer to the root of the problem [ link ].

Imagining things

People store and retrieve information based on self-interest, feelings and mirroring – or mentally simulating an activity. Kind of like watching a tennis match in preparation for a game. When presented with lists of character traits (adventurous, brave, compassionate) participants were asked one of five questions: 

1. what does it rhyme with (phonetic elaboration) 

2. what does it mean (semantic elaboration) 

3. can you identify with it (semantic self-referential processing) 

4. have you ever acted that way (episodic self-referential processing) 

5. can you imagine yourself acting that way now (self-imagining) 

Turns out question 5 (self-imagining) boosts recall more than any of the other questions [ link ].

Resource-based attention

In an elegant ‘simulation’ of economic-class differences, researchers found that people with means (those in higher economic classes) don’t have to focus so much on their immediate needs and are more likely to consider the future cost of borrowing when making purchase decisions. On the other hand, people with limited means, who do have to focus on immediate needs, make better use of the resources they have but lose sight of the future cost of borrowing. As a result, they are more likely to become over-extended [ link ]. This means that no matter who you are, having limited resources alters the way you perceive and make borrowing decisions. They simulated economic differences by altering either the amount of time or the number of opportunities each group had available to make choices. The group with less time made better use of it when making purchase decisions than the group with more time. However, when they were allowed to ‘borrow time’ from future periods, at exorbitant cost .. these advantages diminish. This tells me that it’s not some innate ability to defer gratification that distinguishes rich from poor. When you have less to spend ..your attention is, by necessity, focused on the demands of the present situation.

Level of stress

Locus-of-control affects levels-of-stress. People in charge experience less stress than those whose livelihood is in the hands of others [ link ]. Confidence in keeping their position helps .. even when the organization they lead .. suffers. They test lower for the presence of cortisol among other things.

Neuro news

Neuroscientists have documented the functional neuro-anatomy of the hippocampus and amygdala. They’ve deciphered the role of the hippocampus ..showing how it works to transfer and consolidate information during long-term storage. They have also seen how the amygdala acts to adjust our threshold to threat and assign emotional-value to information transfer. “..what’s unclear however is the way the two regions connect ..and it’s the inter-connectivity that enables complex behavior that occurs so seamlessly.” 

Neuro feedback:  Real-time ‘visual feedback’ showing activity in the brain that’s linked to pain gives patients the ability to adjust and relieve instances of pain. Activity is displayed as a ‘flame’ ..which they can be taught to lower ..thereby reducing the activity and relieving the pain 

Depression :  Anti-depressants have been shown to work by lowering activity in a part of the prefrontal cortex called Broadmann's area 25 [ link ]. According to Neuroscientists “ ..area 25 is a key conduit of neural traffic between the “thinking” frontal cortex and the phylogenetically older limbic region that gives rise to emotion .. area 25 appears overactive in depressed people, like it opens the floodgates and allows negative emotions to overwhelm thinking and mood.” My question is - if they can treat depression in this area with anti-depressants and deep brain stimulation  ....couldn’t they also treat it with neurofeedback training ..?

Network content

“The meaning of a sentence is derived from the original words by an active, interpretive process. The original sentence which is perceived is rapidly forgotten and the memory is then for the information (meaning) contained in the sentence.” ~ Jacqueline Sachs, 1967 

Apparently the effect of messages from our peers is greater than the content of the messages themselves. James Fowler at UCSD conducted a study to observe the influence of messages read on Facebook [ link ]. He found that messages from peers are more persuasive than purely informational messages. Thirty nine percent more recipients went to the polls and voted after receiving messages from friends reminding them to vote than those who received messages from ‘the sponsor’. This tells me that the power of a message doesn’t reside in the information (meaning) alone.  Or perhaps the social-value is an even greater source of information.

Predictions in social perception

Research has shown that perception is an active process. The brain is constantly making predictions about the outcome of sensory events and revising predictions in response to feedback. Discrepancies naturally occur between expected and actual events resulting in ‘prediction errors’ that the brain actively works to resolve. Although prediction errors are transient in nature, they can be observed and measured during tests of sense-function. The longer they persist, the more disruptive they are to tasks involving high-speed sense-discrimination such as speech and reading comprehension. The principles of “predictive brain” are well established in the field of neuro-cognition. This study suggests they apply to the field of social-cognition as well ..and error analysis could be a useful measure of disruptions in social perception that characterize delusions of mental-illness [link].