PTS prevention study

What makes some people less susceptible to PTS ..? Nociceptin receptors in the amygdala. Nociceptin (NOP) is a compound found at the synapse that acts like an analgesic. Nociceptin receptors are part of the amygdala involved in conditioned fear. According to neuroscientist Raul Andero Gali, we can prevent PTSD-like symptoms from developing.

Animal model of PTS

Traumatic   ~>    Fear-Response   ~>   Extinction
   Event                 Conditioning              Training  

During extinction training, some animals unlearn fear response (freezing) more rapidly than others. Persistence of fear in absence of danger is a characteristic of PTS. So, what makes some animals less susceptible to PTS ..?

Study 1 – naturalistic observation

Study found that those who unlearn the fastest were those whose Nociceptin receptors were most active. Nociceptin is a natural occurring opiate in the brain that’s thought to dampen consolidation of fearful memories 

Study 2 – experimental method

Animals that received a drug during conditioning that activates Nociceptin receptors  quickly learned to stop fearing the tone during extinction training. NOP receptors may interfere with fear memory consolidation, with implications for prevention of PTSD after a traumatic event [link] [link].

Level of stress

Locus-of-control affects levels-of-stress. People in charge experience less stress than those whose livelihood is in the hands of others [ link ]. Confidence in keeping their position helps .. even when the organization they lead .. suffers. They test lower for the presence of cortisol among other things.

Anti-anxiety

The complaint I most frequently hear from former pot smokers of my generation (those who came-of-age during the 60’s and 70’s) ..is that smoking marijuana makes them feel nervous. Some describe it as so intense, it borders on paranoia. Consequently they quit and never came back. In the day, little was known about cultivating for the psychoactive effects of marijuana.

The times they are a’ changing. A new breed of cultivator has revolutionized the field. They can grow sophisticated varietals with a range of psychoactive properties. “The THC component is the same ..it is the mixture of other elements that play a vital role in changing the psychoactive effect.” Two decades ago, most marijuana smokers bought whatever their dealer had. It was illegal even for research purposes. Consequently nothing was known about marijuana other than its THC content.

One of these newly found elements is a compound called Cannabidoil or CBD. It’s responsible for the calming and pain relieving effects found in medicinal marijuana. Takes the buzz off THC so to speak. CBD is also helpful in treating a range of problems, including arthritis, the side effects of chemotherapy, asthma, sleep disorders and post-traumatic stress disorder [ link ]. CBD is measured in grams. Your local dispensary should carry varieties containing different amounts of CBD .. 0.35 grams being considered ‘good’.